The LS is the best example I know of, but I make these a lot- it's all in Intent when you craft the sigil, and looking at it as a spell filter that programs your magick as it passes through rather than the spell itself. Most people craft sigils to BE one time use- just in how they think about it. Change your thinking, change the way it works. So long as it's a general sort of spell, you just do the targeting bit with your mind as you fire it, or have a spot to plug in a target symbol.
Once you get the trick of making your symbol Mean what you want it to mean, then anyone can use that symbol/sigil, and get the same or a similar effect (the personal resonance of the caster does seem to alter the result or manifestation path)
Take protection, for instance- the most common one I use for talismans is a double layered circle with three dividing lines and C O P in my personal alphabet (for cirlce of protection- simple is best) and since I've Named that symbol, anytime I use it, it functions as such. To target it for a particular person, I make a bindrune of their initials and stick that in the center, and voilla! since I use Ellis as a powersource inside the talisman itself, it provides a constant low to mid level charge, and if someone's really getting nailed they use the talisman as a focus, run their own voo through it, and the sigil funnels that into the protection spell.
I also make Schematic sigils- I have a number of general constructs for protection, reality usurping, deflection, "energy direction"- all the stuff you'd DO with sigils, but have to spell out and break back down to craft single use ones- since I have these symbol constructs I can just write in my special alphabet a few general words about what I'm dealing with, throw in my appropriate constructs where they need to go between these ideas/targets/energies, and I've rapidly got a very complex sigil spell filter ready to go without much fuss.
you can also use this same concept with words or hand gestures- like I've got a spell for mental focus, control, empathic shielding, and calming that I use a specific hand gesture to perform. The hand gesture is my spell filter. I do that and put the voo to it, the spell does its thing- just like a drawn or imagined sigil- this physical trigger is especially handy when my mind is too overwhelmed (especially in a highly emotionally charged situation) to focus, and acts as a back door of sorts to get my mind right.
hope some of that was helpful.